Related Experiment Video
Updated: Jun 17, 2026

07:20
Detecting the Lyme Disease Spirochete, Borrelia Burgdorferi, in Ticks Using Nested PCR
Published on: February 4, 2018
[Tick-borne encephalitis after a holiday in Southern Germany]
Anna-Christa Q de Vries1, Jessica de Ruijter, Mariana de Mendonça Melo
1Havenziekenhuis, Afd. Interne geneeskunde, Academisch Medisch Centrum, Rotterdam, The Netherlands.
Nederlands Tijdschrift Voor Geneeskunde
|January 7, 2010
Summary
A tick-borne encephalitis (TBE) case in Southern Germany presented with biphasic illness after tick bites. Diagnosis was confirmed serologically, highlighting the importance of vaccination in endemic areas.
Area of Science:
- Neurology
- Infectious Diseases
- Virology
Background:
- Tick-borne encephalitis (TBE), also known as Frühsommer-Meningoenzephalitis (FSME), is a viral infection transmitted by ticks.
- Southern Germany is an endemic region for TBE virus (TBEV).
- The illness often presents with a biphasic clinical course.
Observation:
- A 56-year-old male presented with headache, fever, and photophobia.
- The patient reported a history of tick bites in Southern Germany and a preceding flu-like illness.
- The illness exhibited a biphasic course, a characteristic pattern of TBE.
Findings:
- Serological tests confirmed the diagnosis of TBE.
- The biphasic course occurred in 72-87% of TBE cases.
- Prognosis is influenced by the specific virus subtype and the extent of central nervous system involvement.
Implications:
- Symptomatic treatment is the primary approach for TBE.
- Residual neurological symptoms can occur in affected patients.
- Active immunization is recommended for individuals with frequent or prolonged exposure in endemic TBE areas.
Related Concept Videos
Encephalitis l: Introduction
Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
Arboviral Encephalitis
Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
Rocky Mountain Spotted Fever
Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
Encephalitis ll: Pathophysiology
Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
Toxoplasmosis
Toxoplasmosis, a zoonotic disease caused by the protozoan Toxoplasma gondii, poses significant public health challenges globally due to its high seroprevalence and varied clinical manifestations. As an obligate intracellular parasite, T. gondii can infect all warm-blooded vertebrates, but felids are its only definitive hosts, shedding unsporulated oocysts into the environment. Humans typically acquire the infection through ingestion of tissue cysts in undercooked meat or oocysts from...
Viral Meningitis
Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...

