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Related Experiment Video

Updated: Jun 17, 2026

Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice

Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice

Published on: June 27, 2020

[Professor Pel and 'glandular fever'].

Jan van Gijn¹, Joost Gijselhart

¹Vereniging Nederlands Tijdschrift voor Geneeskunde, Amsterdam, The Netherlands. Jan@vanGijn.com

Nederlands Tijdschrift Voor Geneeskunde

|January 7, 2010

Summary

Professor Pieter Klaesz Pel is recognized for his work on periodic fever, spleen, and lymphatic system enlargement. The association of these symptoms with Hodgkin

Area of Science:

Internal Medicine
Hematology
Oncology

Background:

Pieter Klaesz Pel (1852-1919) was a distinguished professor of internal medicine at the University of Amsterdam for over 35 years.
Pel's name is historically associated with a specific clinical presentation involving periodic fever, splenomegaly, and lymphadenopathy.

Discussion:

The condition linked to Pel and Ebstein involves recurrent fevers accompanied by enlarged spleen and lymphatic tissues.
There is ongoing debate regarding the accurate diagnosis of these patients, specifically whether they suffered from Hodgkin's disease.

Key Insights:

The Pel-Ebstein syndrome describes a constellation of symptoms including periodic fever and systemic enlargement of lymphoid organs.
Differential diagnosis remains crucial, as the distinction between this syndrome and other lymphoproliferative disorders like Hodgkin's disease is contested.

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Outlook:

Further research may clarify the underlying pathophysiology of Pel-Ebstein syndrome.
Improved diagnostic criteria could aid in differentiating this condition from Hodgkin's disease and other hematologic malignancies.