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Related Concept Videos

Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

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Related Experiment Video

Updated: Jun 17, 2026

Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions
09:34

Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions

Published on: November 27, 2017

Stem cells: roadmap to the clinic.

George Q Daley1

  • 1Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Manton Center for Orphan Disease Research, Howard Hughes Medical Institute, Boston, Massachusetts, USA. george.daley@childrens.harvard.edu

The Journal of Clinical Investigation
|January 7, 2010
PubMed
Summary
This summary is machine-generated.

This review separates stem cell biology hype from reality, detailing a decade of progress and future challenges in regenerative medicine. It balances the promise of stem cell therapies with the hurdles in translating research into clinical applications.

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Induced Pluripotent Stem Cell Generation from Blood Cells Using Sendai Virus and Centrifugation
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Induced Pluripotent Stem Cell Generation from Blood Cells Using Sendai Virus and Centrifugation

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Last Updated: Jun 17, 2026

Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions
09:34

Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions

Published on: November 27, 2017

Induced Pluripotent Stem Cell Generation from Blood Cells Using Sendai Virus and Centrifugation
09:57

Induced Pluripotent Stem Cell Generation from Blood Cells Using Sendai Virus and Centrifugation

Published on: December 21, 2016

Area of Science:

  • Regenerative Medicine
  • Stem Cell Biology
  • Biomedical Research

Background:

  • The field of stem cell biology has seen significant attention, often characterized by terms like "promise" and "future therapies."
  • A gap exists between the potential of stem cell research and its clinical application.
  • Numerous publications highlight rapid advancements, necessitating a clear assessment of the field's status.

Purpose of the Study:

  • To provide a balanced perspective on the state of stem cell research.
  • To differentiate between the hype and the reality of stem cell applications.
  • To review the achievements and future directions in stem cell biology and regenerative medicine.

Main Methods:

  • Review of scientific literature over the past decade.
  • Analysis of major advances and challenges in stem cell research.
  • Synthesis of information to provide a balanced overview.

Main Results:

  • Stem cell biology has made considerable progress over the last decade.
  • Significant challenges remain in translating stem cell research into proven therapies.
  • The field is moving towards regenerative and repair applications for diseased tissues.

Conclusions:

  • A critical evaluation is needed to separate the promise from the reality in stem cell therapies.
  • Understanding the challenges is crucial for the successful translation of stem cell science.
  • Continued research and development are essential for realizing the therapeutic potential of stem cells.