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Related Concept Videos

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Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Related Experiment Video

Updated: Jun 17, 2026

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
09:03

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Published on: August 25, 2019

Update on procedure-related risks for prenatal diagnosis techniques.

Ann Tabor1, Zarko Alfirevic

  • 1Department of Fetal Medicine, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. ann.tabor@rh.regionh.dk

Fetal Diagnosis and Therapy
|January 7, 2010
PubMed
Summary

Invasive prenatal diagnostic procedures like amniocentesis and chorionic villus sampling (CVS) carry a 0.5-1.0% miscarriage risk. Optimal timing is crucial to minimize complications and ensure patient safety.

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Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
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Published on: August 17, 2022

Area of Science:

  • Prenatal Diagnosis
  • Medical Procedures
  • Risk Assessment

Background:

  • Effective screening methods have led to a decline in invasive prenatal diagnostic procedures.
  • This review focuses on summarizing the risks associated with these procedures.

Purpose of the Study:

  • To review and summarize the risks associated with invasive prenatal diagnostic procedures.
  • To provide evidence-based guidance on the optimal timing for amniocentesis and chorionic villus sampling (CVS).

Main Methods:

  • Literature review of randomized controlled trials, systematic reviews, and national registry studies.

Main Results:

  • Amniocentesis and chorionic villus sampling (CVS) have a procedure-related miscarriage rate of 0.5-1.0%.
  • Amniocentesis before 15 weeks increases miscarriage and talipes equinovarus risk; CVS before 10 weeks increases limb reduction defect risk.
  • Operator skill significantly impacts success and complication rates.

Conclusions:

  • Experienced operators achieve higher success and lower complication rates in invasive prenatal procedures.
  • Decreasing procedure numbers necessitate quality assurance and operator performance monitoring.