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Microparticles, vascular function and hypertension

Chantal M Boulanger1

  • 1INSERM U970, Paris Cardiovascular Research Center-PARCC, Paris, France. Chantal.boulanger@inserm.fr

Current Opinion in Nephrology and Hypertension
|January 7, 2010
PubMed
Abstract

Insights

Circulating endothelial microparticles are elevated in cardiovascular diseases and may indicate arterial damage. These microparticles also play a role in vascular repair, offering prognostic value.

Area of Science:

  • Cardiovascular Biology
  • Cellular Biology

Background:

  • Microparticles are submicron vesicles released during cell activation or apoptosis.
  • Elevated microparticle levels are observed in patients with cardiovascular diseases.

Purpose of the Study:

  • To review the role of microparticles in hypertension and cardiovascular diseases.
  • To highlight endothelial microparticles as potential biomarkers.

Main Methods:

  • Literature review of recent studies on microparticles.
  • Analysis of microparticle origins and their association with disease states.

Main Results:

  • Endothelial microparticles increase with endothelial dysfunction in cardiovascular disease patients.
  • Endothelial microparticles serve as a surrogate marker for endothelial dysfunction.
  • Microparticles are implicated in inflammation, vascular injury, angiogenesis, and thrombosis.

Conclusions:

  • Circulating endothelial microparticles can indicate arterial damage.
  • Endothelial microparticles may also act as triggers for vascular repair.

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