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Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
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Parkinson's disease spatial covariance pattern: noninvasive quantification with perfusion MRI.

Yilong Ma1, Chaorui Huang, Jonathan P Dyke

  • 1Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|January 7, 2010
PubMed
Summary

Parkinson's disease (PD) shows elevated patterns in brain scans. Continuous arterial spin labeling perfusion MRI accurately quantifies these disease-related patterns, correlating well with PET imaging.

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Area of Science:

  • Neuroimaging
  • Radiology
  • Neurology

Background:

  • Parkinson's disease (PD) is linked to specific spatial covariance patterns in brain scans.
  • These patterns reflect alterations in cerebral blood flow and metabolism.

Purpose of the Study:

  • To evaluate continuous arterial spin labeling perfusion MRI (CASL pMRI) for quantifying PD-related patterns.
  • To compare CASL pMRI findings with established PET imaging in early-stage PD.

Main Methods:

  • Nine early-stage Parkinson's disease patients and nine healthy controls underwent CASL pMRI scans.
  • Parkinson's disease-related pattern (PDRP) expression was analyzed in both groups.
  • CASL pMRI results were compared against (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) data.

Main Results:

  • PDRP expression was significantly elevated in PD patients across both imaging modalities (P<0.01).
  • A strong correlation was observed between PDRP values derived from CASL pMRI and FDG-PET (P<0.0001).

Conclusions:

  • CASL pMRI is a viable method for accurate quantification of disease-related covariance patterns in Parkinson's disease.
  • Perfusion MRI offers a promising alternative for assessing PD-related metabolic changes.