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Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
Published on: March 20, 2015
Remote surface enhanced Raman spectroscopy imaging via a nanostructured optical fiber bundle
Valérie Guieu1, Patrick Garrigue, François Lagugné-Labarthet
1Université Bordeaux 1, Institut des Sciences Moléculaires, UMR CNRS 5255, 351 Cours de la Libération, 33405 Talence cedex, France.
Optics Express
|January 7, 2010
Summary
Remote surface enhanced Raman spectroscopy (SERS) imaging was achieved using an optical fiber with a nanostructured tip. This technique successfully detected benzene thiol, enabling localized remote imaging with a SERS-active platform.
Area of Science:
- Optoelectronics
- Spectroscopy
- Nanotechnology
Background:
- Surface-enhanced Raman spectroscopy (SERS) offers high sensitivity for molecular detection.
- Integrating SERS with optical fibers enables remote sensing capabilities.
- Challenges include signal interference from fiber materials.
Purpose of the Study:
- To demonstrate remote SERS imaging of adsorbed monolayers using an optical fiber.
- To develop a SERS-active platform integrated into an optical fiber.
- To overcome signal interference from fiber optics.
Main Methods:
- Fabrication of a nanostructured array of conical tips on an optical fiber bundle.
- Inscribing the nanostructure onto the distal face of the fiber.
- Performing SERS imaging of an adsorbed benzene thiol monolayer.
Main Results:
- Successful detection of benzene thiol's Raman signal in the fingerprint region.
- Demonstrated remote SERS imaging capability despite fiber optic signal interference.
- Validated the SERS-active platform integrated into the optical fiber.
Conclusions:
- Remote SERS imaging of adsorbed monolayers is feasible using optical fibers.
- The developed fiber-optic SERS platform enables localized remote chemical analysis.
- This technology holds promise for in-situ and remote molecular detection applications.
