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Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention

Published on: October 16, 2013

Suspected recurrent anaphylaxis in different forms during general anesthesia.

Hirokazu Imanishi¹, Akira Kitamura, Kouichi Maruyama

¹Department of Anesthesiology, Saitama International Medical Center, Saitama Medical University, 1397-1 Yamane, Hidaka, Saitama, 350-1298, Japan.

Journal of Anesthesia

|January 7, 2010

Summary

This summary is machine-generated.

Anesthetists should consider diverse allergic reactions in patients experiencing recurrent shock during surgery. Rigorous investigation of all agents and phenomena is crucial for patient safety.

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Measuring Local Anaphylaxis in Mice

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Published on: October 14, 2014

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Last Updated: Jun 17, 2026

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention

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Published on: October 16, 2013

Measuring Local Anaphylaxis in Mice

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

Area of Science:

Anesthesiology
Allergy and Immunology
Cardiology

Background:

Recurrent severe shock during general anesthesia is a rare but critical clinical challenge.
Identifying the underlying cause of anaphylactic or allergic reactions is paramount for effective management.

Observation:

A patient undergoing lung surgery experienced two episodes of shock: first coronary spasm, then bronchospasm and hypotension.
Elevated serum tryptase levels were detected, suggesting an allergic or mast cell activation disorder.

Findings:

Skin testing for common anesthetic drugs yielded negative results, complicating the diagnosis.
The patient's presentation indicated a complex, possibly atypical, hypersensitivity reaction.

Implications:

This case underscores the need for anesthetists to consider a broader spectrum of allergic responses beyond typical anaphylaxis.
Thorough investigation of all anesthetic agents, adjuncts, and patient-specific factors is essential for diagnosing and preventing recurrent shock.
Highlights the importance of recognizing unusual presentations of hypersensitivity in perioperative settings.