Related Experiment Video

Updated: Jun 17, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
09:14

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine

Published on: February 16, 2018

[Biosynthesis of L-lysine-alpha-oxidase, an antitumor enzyme, by Trichoderma spp]

I P Smirnova, S B Alekseev, A A Shevchenko

    Antibiotiki I Khimioterapiia = Antibiotics and Chemoterapy [Sic]
    |January 8, 2010
    PubMed

    Insights

    Researchers studied Trichoderma spp. strains for L-lysine-alpha-oxidase production, showing potential in chemotherapy. The enzyme

    Area of Science:

    • Biochemistry
    • Enzymology
    • Mycology

    Context:

    • Trichoderma spp. produce L-lysine-alpha-oxidase.
    • This enzyme shows potential for malignant tumor chemotherapy.
    • Brevibacterium sp. can induce this enzyme activity.

    Purpose:

    • To study Trichoderma spp. strains for L-lysine-alpha-oxidase production.
    • To optimize enzyme biosynthesis.
    • To investigate enzyme activity spectra at various pH levels.

    Summary:

    • Optimal L-lysine-alpha-oxidase biosynthesis occurred on wheat bran medium.
    • Trichoderma spp. exhibited highest activity in L-lysine destruction.
    • Brevibacterium sp. induced L-lysine-alpha-oxidase activity in Trichoderma spp.

    Impact:

    • Identifies specific Trichoderma spp. strains for enzyme production.
    • Provides insights into enzyme activity regulation.
    • Suggests a method for enhancing L-lysine-alpha-oxidase production for potential therapeutic applications.

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