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Related Concept Videos

Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...

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Related Experiment Video

Updated: Jun 17, 2026

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
06:35

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Published on: June 28, 2021

[Fulminant acute pancreatitis].

Z Krska1, J Sváb

  • 1I. Chirurgická klinika 1. LF UK a VFN v Praze. krskaz@vfn.cz

Rozhledy V Chirurgii : Mesicnik Ceskoslovenske Chirurgicke Spolecnosti
|January 8, 2010
PubMed
Summary
This summary is machine-generated.

Fulminant acute pancreatitis (FAP) and subfulminant pancreatitis (SFAP) are severe forms of acute pancreatitis with high mortality. Early organ failure and hyperlipidemia are key indicators, with surgical treatment showing more impact in SFAP.

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Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
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Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
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Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
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Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct

Published on: April 1, 2022

Area of Science:

  • Gastroenterology
  • Critical Care Medicine
  • Pathology

Context:

  • Fulminant acute pancreatitis (FAP) and subfulminant pancreatitis (SFAP) are severe subgroups of severe acute pancreatitis (SAP).
  • These conditions are characterized by rapid organ failure (OF) and multi-organ failure (MOF), leading to high mortality.
  • Existing conservative and surgical treatments have shown limited efficacy.

Purpose:

  • To analyze a cohort of patients with SAP, specifically FAP and SFAP.
  • To compare findings with existing literature.
  • To investigate the incidence, progression, and lethality of FAP and SFAP.

Summary:

  • The study analyzed 106 SAP patients, including 21 with extremely severe acute pancreatitis (ESAP), of which 6 were FAP and 15 were SFAP.
  • FAP exhibited higher lethality (83%) and shorter survival (4.1 days) than SFAP (67% lethality, 9.2 days survival).
  • Hyperlipidemia/hypercholesterolemia were more prevalent in FAP (60%) compared to SFAP, with biliary or alcohol etiology being more frequent in SFAP.

Impact:

  • Findings confirm the high incidence, progression, and lethality of FAP and SFAP.
  • Early detection of organ failure and its dynamics are crucial for mortality prediction.
  • While intensive care is essential, surgical treatment appears more impactful in SFAP than in FAP.