Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Micelles01:30

Micelles

Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Potentials of Machine Learning in Predicting Key Features of Synthetic Antimicrobial Polymers.

ACS polymers Au·2026
Same author

The effect of temperature on in situ β-cyclodextrin inclusion complex aggregate films at liquid-liquid interfaces.

Journal of colloid and interface science·2026
Same author

Core-block engineering enables control of ice recrystallisation inhibition in polymer nanoparticles.

Chemical science·2026
Same author

Supramolecular Near-Infrared Photocatalysts for Efficient and Oxygen-Tolerant Aqueous RAFT Polymerization.

Angewandte Chemie (International ed. in English)·2026
Same author

Rational design of pigment-polymer antenna complexes.

Chemical science·2026
Same author

Mechanically Robust Ultrahigh Molecular Weight Supramolecular Hydrogels Reinforced by Synergistic Chain Entanglement, Hydrogen Bonding, and Nanoparticle Incorporation.

Angewandte Chemie (International ed. in English)·2026

Related Experiment Video

Updated: Jun 17, 2026

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
10:53

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

Polymeric microcapsules assembled from a cationic/zwitterionic pair of responsive block copolymer micelles.

Timothy Addison1, Olivier J Cayre, Simon Biggs

  • 1Institute of Particle Science & Engineering, University of Leeds, Leeds LS2 9JT, United Kingdom. pre1twa@leeds.ac.uk

Langmuir : the ACS Journal of Surfaces and Colloids
|January 8, 2010
PubMed
Summary

This study demonstrates hollow microcapsules made entirely from pH-responsive block copolymer micelles using a layer-by-layer approach. These robust, dye-loaded capsules show potential for encapsulation and triggered release applications.

More Related Videos

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
09:57

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Related Experiment Videos

Last Updated: Jun 17, 2026

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
10:53

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
09:57

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Nanotechnology

Background:

  • Layer-by-layer (LbL) assembly is a versatile technique for creating multilayered materials.
  • pH-responsive block copolymer micelles offer tunable properties for advanced applications.
  • Sacrificial templates are crucial for forming hollow structures, requiring careful optimization of dissolution conditions.

Purpose of the Study:

  • To develop hollow microcapsules using a pH-responsive block copolymer micelle system.
  • To investigate the use of calcium carbonate as a sacrificial template for LbL assembly.
  • To confirm the structural integrity and functionality of the resulting hollow capsules.

Main Methods:

  • Utilized a layer-by-layer (LbL) approach with alternating anionic and cationic pH-responsive block copolymer micelles.
  • Employed calcium carbonate particles as sacrificial templates, dissolved using ethylenediaminetetraacetic acid (EDTA).
  • Characterized the hollow microcapsules using atomic force microscopy (AFM), scanning electron microscopy (SEM), quartz crystal microbalance, and thermogravimetric analysis (TGA).

Main Results:

  • Successfully fabricated hollow microcapsules with membranes composed solely of pH-responsive block copolymer micelles.
  • Demonstrated the robustness of the micelle multilayer membrane after template removal.
  • Confirmed retention of encapsulated hydrophobic dye within the hollow capsules, indicating intact micelle core-shell structures.
  • Verified complete removal of the calcium carbonate template via TGA.

Conclusions:

  • This work presents the first LbL-assembled capsules made entirely from responsive block copolymer micelles.
  • The developed method provides robust hollow capsules with potential for encapsulation and triggered release.
  • Optimized template dissolution conditions preserve micelle responsiveness and capsule integrity.