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Related Concept Videos

Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
Drug Discovery: Overview01:26

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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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In vitro dissolution and drug release tests assess how quickly and how much of a drug is released from its dosage form into an aqueous medium under standardized laboratory conditions. These tests are essential tools in pharmaceutical development and quality assurance, offering insight into the drug's performance before clinical use.During formulation development, dissolution testing identifies incomplete or inconsistent drug release issues. It also supports decisions on selecting the optimal...
Design Example: Managing Concrete Workability01:14

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This example deals with managing the workability of concrete for a raft foundation project under hot weather conditions. Workability is crucial for ensuring the concrete is easy to place, compact, and finish. In this scenario, a slump test — a common method to measure the workability of fresh concrete — initially indicated low workability. This was attributed to the rapid water loss from the concrete mix, exacerbated by the high temperatures causing the course aggregates to heat up.
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Clinical Trials: Overview01:11

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Product specifications define the acceptable quality of a pharmaceutical product by ensuring identity, purity, potency, and strength. These specifications serve as benchmarks during development, manufacturing, and post-approval quality control. Clinically relevant specifications are particularly important because they directly relate to a drug's safety and efficacy in clinical use.Dissolution studies are critical biopharmaceutic tools that link in vitro behavior to in vivo performance. They...

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Discovery and Synthesis Optimization of Isoreticular Al(III) Phosphonate-Based Metal-Organic Framework Compounds Using High-Throughput Methods
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Discovery and Synthesis Optimization of Isoreticular Al(III) Phosphonate-Based Metal-Organic Framework Compounds Using High-Throughput Methods

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Preformulation designed to enable discovery and assess developability.

Michael J Hageman1

  • 1Bristol Myers-Squibb Research and Development, Discovery Pharmaceutics in Pharmaceutical Candidate Optimization, Route 206 & Province Line Road, Princeton, New Jersey 08540, USA. michael.hageman@bms.com

Combinatorial Chemistry & High Throughput Screening
|January 8, 2010
PubMed
Summary
This summary is machine-generated.

Understanding drug molecule physicochemical properties is crucial for successful drug development. Addressing these properties early improves drug design, reduces costs, and increases the likelihood of a candidate

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Published on: December 11, 2016

Area of Science:

  • Drug discovery and development
  • Medicinal chemistry
  • Pharmaceutical sciences

Background:

  • Physicochemical properties significantly influence drug behavior in vivo and in vitro.
  • Poor properties impede structure-activity relationship (SAR) studies, in vivo models, and increase development costs.
  • These challenges can halt or complicate the drug development process.

Purpose of the Study:

  • To review key physicochemical properties of drug molecules.
  • To discuss methods for assessing these properties.
  • To explain their role in both drug discovery and product developability.

Main Methods:

  • Literature review of physicochemical properties in drug development.
  • Discussion of assessment techniques for molecular properties.
  • Analysis of property implications on discovery and developability.

Main Results:

  • Physicochemical properties are fundamental to drug behavior and development success.
  • Early assessment and mitigation of poor properties are vital.
  • Understanding these properties aids in selecting viable drug candidates.

Conclusions:

  • Optimizing physicochemical properties early in drug design is essential for efficient development.
  • This understanding enhances the probability of a drug candidate successfully navigating the development pipeline.
  • Addressing molecular properties impacts performance, cost, and overall project execution.