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Updated: Jun 17, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
Published on: September 8, 2015
Gene polymorphisms and prostate cancer: the evidence
Seyed S Dianat1, Markus Margreiter, Elisabeth Eckersberger
1Department of Urology, School of Medicine, New York University, NY, USA.
Genetic variations in prostate cancer show inconsistent results, with vitamin D receptor gene studies being particularly conflicting. Angiogenesis and cell adhesion genes show more promise for future therapeutic targets in prostate cancer research.
Area of Science:
- Oncology
- Genetics
- Molecular Biology
Background:
- Prostate cancer is a leading cause of cancer death in men.
- Genetic factors play a significant role in prostate cancer development and progression.
- Genome-wide association studies (GWAS) are increasingly important for identifying genetic links.
Purpose of the Study:
- To review the association between critical genes and pathways and prostate cancer.
- To analyze existing literature on gene polymorphisms and their link to prostate cancer risk.
- To identify promising genetic markers for diagnosis, therapy, and prognosis.
Main Methods:
- Conducted a PubMed literature search from 1997 to 2009.
- Used keywords including "prostate cancer," gene names, and "polymorphisms."
- Reviewed retrieved articles and relevant related studies.
Main Results:
- Studies on gene polymorphisms in prostate cancer yielded conflicting results.
- Vitamin D receptor gene polymorphism studies showed the most inconsistency.
- Genes involved in angiogenesis and cell adhesion appear more promising for prostate cancer research.
Conclusions:
- Ethnic differences, sample size, and modifying factors contribute to inconsistent findings.
- Expansion of GWAS to diverse populations is recommended.
- Future research should explore gene-environment and gene-diet interactions in prostate cancer.
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