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Influenza virus infection among pediatric patients reporting diarrhea and influenza-like illness

Charisma Dilantika1, Endang R Sedyaningsih, Matthew R Kasper

  • 1Naval Medical Research Unit No 2, Jakarta, Indonesia.

BMC Infectious Diseases
|January 8, 2010
PubMed

Insights

Influenza virus RNA was found in the stool of children with diarrhea, suggesting the gastrointestinal tract is involved and may spread influenza during outbreaks.

Area of Science:

  • Pediatric Infectious Diseases
  • Virology
  • Gastroenterology

Background:

  • Influenza commonly causes morbidity and hospitalization in children.
  • Gastrointestinal symptoms like diarrhea are associated with pediatric influenza.

Purpose of the Study:

  • To determine the frequency of influenza virus infection in pediatric patients with diarrhea.
  • To investigate influenza virus presence in stool samples from children with influenza-like illness.

Main Methods:

  • Pediatric patients with concurrent diarrhea and influenza-like illness were enrolled in Indonesia (2005-2008).
  • Stool and upper respiratory swabs were tested for influenza virus.
  • Avian influenza A (H5N1) virus infection was specifically monitored.

Main Results:

  • Influenza A or B viral RNA detected in 11.6% of respiratory swabs and 2.9% of stool specimens.
  • Viable influenza B virus isolated from one stool sample.
  • No H5N1 avian influenza virus infections were found among 733 subjects.

Conclusions:

  • Influenza virus RNA and viable virus in stool suggest gastrointestinal localization in children.
  • Influenza virus may contribute to pediatric diarrhea.
  • The gastrointestinal tract may be a transmission route during influenza outbreaks.
Abstract

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