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Related Concept Videos

Crossing Over01:30

Crossing Over

Crossing over is the exchange of genetic information between homologous chromosomes during prophase I of meiosis I. Genetic recombination gives rise to allelic diversity in the newly formed daughter cells. In humans, crossing over produces genetically distinct haploid egg and sperm cells that undergo fertilization to produce unique offspring. Before cell division starts, the germ cell’s chromosome(s) undergo duplication in the S phase of the cell cycle. As the cells enter prophase I, duplicated...
Crossing Over01:34

Crossing Over

Unlike mitosis, meiosis aims for genetic diversity in its creation of haploid gametes. Dividing germ cells first begin this process in prophase I, where each chromosome—replicated in S phase—is now composed of two sister chromatids (identical copies) joined centrally.
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process called synapsis.
In order to...
Crossing over01:34

Crossing over

Unlike mitosis, meiosis aims for genetic diversity in its creation of haploid gametes. Dividing germ cells first begin this process in prophase I, where each chromosome—replicated in S phase—is now composed of two sister chromatids (identical copies) joined centrally.
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process called synapsis.
In order to...
Social Traps01:41

Social Traps

Social traps are negative situations where people get caught in a direction or relationship that later proves to be unpleasant, with no easy way to back out of or avoid. The concept was orignally introduced by John Platt who applied psychology to Garrett Hardin's "Tragedy of the Commons", where in New England herd owners could let their cattle graze in the common ground. This situation seems like a good idea, but an individual could have an advantage. If they owned more cows, the larger...
Schemas01:42

Schemas

A schema is a mental construct consisting of a cluster or collection of related concepts (Bartlett, 1932). There are many different types of schemata, and they all have one thing in common: schemata are a method of organizing information that allows the brain to work more efficiently. When a schema is activated, the brain makes immediate assumptions about the person or object being observed.
Routes of Persuasion02:20

Routes of Persuasion

Persuasion is the process of changing our attitude toward something based on some kind of communication. Much of the persuasion we experience comes from outside forces. How do people convince others to change their attitudes, beliefs, and behaviors? What communications do you receive that attempt to persuade you to change your attitudes, beliefs, and behaviors?

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Related Experiment Video

Updated: Jun 17, 2026

Iris Fixation via External Pentagram Suturing
05:22

Iris Fixation via External Pentagram Suturing

Published on: May 5, 2022

Scribble at the crossroads.

Sandrine Etienne-Manneville1

  • 1Institut Pasteur, Cell Polarity and Migration Group and CNRS URA 2582, 25 rue du Dr Roux, 75724 Paris cedex 15, France. sandrine.etienne-manneville@pasteur.fr

Journal of Biology
|January 8, 2010
PubMed
Summary
This summary is machine-generated.

Scribble, a tumor suppressor, influences cell polarity and cancer. This study clarifies its downstream signaling pathways controlling cell growth and programmed cell death, advancing cancer research.

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Cancer Research

Background:

  • Proteins regulating apical-basal cell polarity are implicated in tumorigenesis.
  • The exact mechanisms linking cell polarity proteins to cancer remain incompletely understood.

Purpose of the Study:

  • To elucidate the signaling pathways controlled by the tumor suppressor Scribble.
  • To clarify Scribble's role in regulating cell polarity, proliferation, and apoptosis.

Main Methods:

  • Analysis of signaling pathways downstream of Scribble.
  • Investigating the impact of Scribble on cell polarity, proliferation, and apoptosis.

Main Results:

  • Identified key signaling pathways regulated by Scribble.
  • Demonstrated Scribble's influence on cell polarity maintenance.
  • Showcased Scribble's role in controlling cell proliferation and apoptosis.

Conclusions:

  • Scribble is a crucial regulator of cell polarity, proliferation, and apoptosis.
  • Understanding Scribble's pathways provides insights into tumorigenesis.
  • This work clarifies the molecular mechanisms underlying Scribble's tumor-suppressive functions.