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Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles
Published on: October 19, 2015
Cu2+-labeled, SPION loaded porous silica nanoparticles for cell labeling and multifunctional imaging probes
Daksha Patel1, Arnold Kell, Benoit Simard
1Steacie Institute for Molecular Science, National Research Council of Canada, 100 Sussex Drive, Ottawa, Ontario K1A0R6, Canada. daksha.patel@nrc-cnrc.gc.ca
Abstract:
We have developed an ion-sensing nanoparticle that is comprised of a superparamagnetic iron oxide (SPIO) core encapsulated with a porous silica shell. The latter can be readily anchored with ligands capable of coordinating with positron-emitting metal. Evidently, this nanoparticle has a great potential for use in cell tracking with magnetic resonance (MR) imaging and positron emission tomography (PET). Herein we report the synthesis, surface functionalization and characterization of the magnetic nanoparticle-based probes and evaluate their cell-labeling efficacy, cytotoxicity and relaxivity in comparison to one of the most commonly utilized MRI contrast agents, Feridex.

