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High-sensitivity C-reactive protein and total antioxidant status in patients with essential arterial hypertension and

A M Kuklinska1, B Mroczko, W J Musial

  • 1Department of Cardiology, Medical University, Bialystok, Poland. agnieszka.kuklinska@gmail.com

Advances in Medical Sciences
|January 8, 2010
PubMed

Insights

Systemic inflammation, measured by high-sensitivity C-reactive protein (hs-CRP), and antioxidant status (TAS) are significant factors in essential arterial hypertension (HTN). These markers, along with traditional risk factors, aid in diagnosing HTN.

Area of Science:

  • Cardiology
  • Biochemistry
  • Inflammation Research

Background:

  • Essential arterial hypertension (HTN) is a complex condition with multifactorial pathophysiology.
  • Traditional risk factors for HTN include abnormal lipid profiles.
  • The role of low-grade systemic inflammation and antioxidant status in HTN requires further investigation.

Purpose of the Study:

  • To assess low-grade systemic inflammation and antioxidant status as contributors to essential arterial hypertension (HTN) pathophysiology.
  • To compare the diagnostic usefulness of inflammatory and antioxidant markers with traditional risk factors for HTN.
  • To evaluate the potential of hs-CRP and TAS as diagnostic tools for HTN.

Main Methods:

  • Serum high-sensitivity C-reactive protein (hs-CRP) and total antioxidant status (TAS) were measured in 71 HTN patients and 72 healthy controls.
  • Lipid profiles, including LDL-C, HDL-C, and TG, were analyzed.
  • Statistical analyses included global linear regression and Receiver Operating Characteristic (ROC) curve analysis.

Main Results:

  • Hypertensive patients exhibited higher hs-CRP levels (median 2.0 mg/L vs 0.4 mg/L) and lower TAS levels (median 1.4 mmol/L vs 1.5 mmol/L) compared to controls.
  • Hypertensives also showed unfavorable lipid profiles (higher LDL-C and TG, lower HDL-C).
  • hs-CRP and TAS demonstrated high diagnostic sensitivity (87% and 89%, respectively). Age, gender, hs-CRP, TAS, and HDL-C influenced HTN occurrence. ROC analysis identified hs-CRP, HDL-C, and TG as significant for HTN diagnosis.

Conclusions:

  • Low-grade systemic inflammation (hs-CRP) and impaired antioxidant status (TAS) are significant factors in HTN pathophysiology.
  • hs-CRP and TAS, alongside traditional risk factors, are valuable for the diagnosis of essential arterial hypertension.
  • These markers offer additional diagnostic utility for HTN, complementing existing risk assessments.
Abstract

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