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Updated: Jun 17, 2026
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Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
Published on: November 1, 2017
A revised scheme for developmental pathways of hematopoietic cells: the myeloid-based model
Hiroshi Kawamoto1, Haruka Wada, Yoshimoto Katsura
1Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, Tsurumi-ku, Yokohama 230-0045, Japan. kawamoto@rcai.riken.jp
International Immunology
|January 8, 2010
Summary
Hematopoietic stem cells (HSCs) differentiate into diverse blood cells. Recent evidence supports the myeloid-based model, suggesting myeloid potential persists longer in developing lymphocytes, challenging the classical model.
Area of Science:
- Hematology
- Developmental Biology
- Immunology
Background:
- Blood cells originate from a common progenitor, the hematopoietic stem cell (HSC).
- Understanding HSC differentiation is key to comprehending blood cell function and therapeutic potential.
- Two main models explain HSC diversification: the classical and the myeloid-based model.
Purpose of the Study:
- To compare the classical and myeloid-based models of hematopoiesis.
- To present recent evidence supporting the myeloid-based model of HSC differentiation.
Main Methods:
- Review and comparison of existing models of hematopoiesis.
- Analysis of recent experimental evidence regarding lineage commitment in HSCs.
Main Results:
- The classical model posits early, separate branching of lymphoid and myelo-erythroid lineages.
- The myeloid-based model suggests prolonged retention of myeloid potential in lymphoid-committed progenitors.
- Recent findings provide support for the myeloid-based model.
Conclusions:
- The myeloid-based model offers a more accurate representation of early hematopoiesis.
- This understanding has implications for regenerative medicine and treating blood disorders.
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01:34Production of Formed Elements
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Most HSCs commit to...