L-arginine as a nutritional prophylaxis against vascular endothelial dysfunction with aging

Area of Science:

• Gerontology
• Cardiovascular Medicine
• Nutritional Science

Background:

• Vascular senescence, characterized by impaired arterial dilation due to endothelial dysfunction, increases cardiovascular disease (CVD) risk with aging.
• L-arginine is an amino acid involved in critical physiological functions, with emerging evidence highlighting its role in vascular endothelial function.

Purpose of the Study:

• To review the potential of L-arginine as a nutritional intervention to mitigate vascular dysfunction associated with aging and CVD.
• To examine how L-arginine modulates vascular inflammation and systemic hormones to positively influence endothelial function.

Main Methods:

• Literature review focusing on studies investigating L-arginine's effects on vascular health in aging and CVD.
• Analysis of L-arginine's biochemical pathways and their impact on endothelial nitric oxide synthase (eNOS) activity.
• Examination of clinical and preclinical data on L-arginine supplementation and vascular outcomes.

Main Results:

• L-arginine supplementation may improve endothelial function by enhancing nitric oxide bioavailability.
• Modulation of inflammatory markers and hormonal balance by L-arginine shows promise in counteracting vascular senescence.
• Evidence suggests L-arginine can positively impact arterial dilation and reduce CVD risk factors.

Conclusions:

• L-arginine represents a potential nutritional strategy to address age-related vascular dysfunction and reduce CVD risk.
• Further research is warranted to establish optimal L-arginine dosages and long-term efficacy in diverse populations.
• Targeting endothelial function with L-arginine may offer a novel approach to promoting cardiovascular health during aging.