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Related Experiment Video

Updated: Jun 17, 2026

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis
06:36

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis

Published on: August 21, 2020

Experimental models to study cell wounding and repair.

Hewan A Belete1, Lindsay M Godin, Randolph W Stroetz

  • 1Thoracic Disease Research Unit, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
|January 8, 2010
PubMed
Summary

Cell membrane repair is vital for survival after injury. The success of this repair depends on cell type and wound characteristics, with various in vitro models aiding study.

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Area of Science:

  • Cell biology
  • Biomedical engineering
  • Physiology

Background:

  • Cell wounding, a loss of plasma membrane integrity, is common in load-bearing tissues.
  • Cells possess repair mechanisms to restore homeostasis after injury.
  • Wound repair efficiency varies by cell type and lesion characteristics.

Purpose of the Study:

  • To review in vitro experimental models of cell wounding.
  • To present new data on alveolar epithelium repair.
  • To understand mechanisms relevant to ventilator-associated lung injury.

Main Methods:

  • Review of established in vitro cell injury models.
  • Experimental investigation of alveolar epithelial cell responses.
  • Analysis of plasma membrane repair probabilities.

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A Tool to Automatically Create Stable and Reproducible Cell-free Gaps for Improving the Reliability of Cell Wound Healing Assay
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Last Updated: Jun 17, 2026

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis
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Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis

Published on: August 21, 2020

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
07:32

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Published on: February 17, 2021

A Tool to Automatically Create Stable and Reproducible Cell-free Gaps for Improving the Reliability of Cell Wound Healing Assay
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A Tool to Automatically Create Stable and Reproducible Cell-free Gaps for Improving the Reliability of Cell Wound Healing Assay

Published on: October 4, 2024

Main Results:

  • In vitro models effectively simulate cellular stress.
  • Alveolar epithelium exhibits specific wounding and repair characteristics.
  • Wound size and cell type significantly influence repair outcomes.

Conclusions:

  • Plasma membrane repair is a fundamental cellular process.
  • In vitro models are crucial for studying cell injury and repair.
  • Understanding these mechanisms is key for conditions like ventilator-associated lung injury.