Related Experiment Video
Updated: Jun 17, 2026

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
Published on: January 15, 2022
A free boundary problem modeling thrombus growth: model development and numerical simulation using the level set
1Department of Applied Mathematics, University of Heidelberg, Im Neuenheimer Feld 293, Heidelberg, Germany. frederic.weller@iwr.uni-heidelberg.de
Abstract:
Recently, neglect of either shear stress, surface saturation, or thrombus growth in mathematical models of platelet deposition has been identified as leading cause of inability to match experimental evidence. While the consideration of shear stress is necessary to obtain at least some qualitative agreement, purely shear-dependent approaches yield notable quantitative discrepancies. In a previous paper, the author demonstrated that surface saturation significantly improves model predictions. However, discrepancies still persist when thrombus growth is neglected. Therefore, the present work develops a free boundary problem which takes this into account. Numerical simulations are performed using the level set method. The results agree well with measurements in stagnation point flow and tubular expansions, which demonstrates the coupling of flow, platelet adhesion, and aggregate growth in primary hemostasis.
More Related Videos
10:23A Computational Modeling Approach to Investigate the Influence of Hyperthermia on the Tumor Microenvironment
Published on: December 1, 2023
09:38A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
Published on: February 14, 2017
Related Concept Videos
Growth Models with Integration: Problem Solving
Typical Model Studies
Turbulent Flow: Problem Solving
Temperature is a key factor in CO2 solubility. In this case, the CO2 gas and the liquid are cooled to 20°C. Lower temperatures enhance...
Newtonian Fluid: Problem Solving
A velocity gradient forms within the fluid when a Newtonian fluid is placed between two parallel plates, with...
Boundary Layer Characteristics
Design Example: Creating a Hydraulic Model of a Dam Spillway