Sustained release tablets containing soluble polymethacrylates: comparison with tableted polymethacrylate IPEC...

Area of Science:

• Pharmaceutical Technology
• Materials Science

Background:

• Sustained drug release formulations are crucial for improving therapeutic efficacy and patient compliance.
• Polymethacrylate polymers offer versatile properties for drug delivery applications.
• Interpolyelectrolyte complexes (IPEC) are one approach for developing sustained-release systems.

Purpose of the Study:

• To compare a novel sustained-release tablet formulation using a binary mixture of polymethacrylate polymers with IPEC tablets.
• To evaluate drug release profiles and tablet compactness of the novel formulation versus IPEC tablets.
• To assess the suitability of the novel formulation for drugs with diverse physicochemical properties.

Main Methods:

• Preparation of sustained-release tablets using a binary mixture of polymethacrylate polymers (Eudragit E-Citrate and Eudragit L-Sodium).
• Preparation of polymethacrylate interpolyelectrolyte complex (IPEC) tablets.
• Comparative analysis of drug release kinetics and tablet compactness.

Main Results:

• Tablets formulated with Eudragit E-Citrate and Eudragit L-Sodium demonstrated superior sustained release characteristics.
• The novel binary mixture formulation exhibited enhanced tablet compactness.
• These advantages were observed in comparison to IPEC tablets prepared under similar conditions and concentrations.

Conclusions:

• The novel sustained-release tablet formulation using a binary mixture of polymethacrylate polymers presents a promising alternative to IPEC tablets.
• This formulation offers improved drug release and physical properties, making it suitable for a wide range of drugs.
• The ease of preparation and enhanced characteristics highlight its potential in pharmaceutical development.