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Updated: Jun 17, 2026

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease
Published on: October 14, 2021
[Optimisation of treatment of Parkinson's disease with levodopa]
Monika Białecka1, Urszula Adamiak, Barbara Gawrońska-Szklarz
1Zakład Farmakologii Doświadczalnej i Klinicznej, Katedra Farmakologii, Pomorska Akademia Medyczna w Szczecinie, Szczecin. monika-bialecka@post.pl
Abstract:
This article presents the major strategies for individualisation and optimisation of levodopa therapy. The relationship between pharmacokinetic and pharmacodynamic effects of levodopa is discussed. Pharmacokinetic parameters in different stages of Parkinson's disease are interpreted. Moreover, the main differences in pharmacokinetics of levodopa formulations and routes of administration are presented. The authors also suggest methods to increase efficacy and safety of levodopa therapy in patients with Parkinson's disease.
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