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Related Concept Videos

Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
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Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
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Related Experiment Video

Updated: Jun 17, 2026

A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection
09:15

A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection

Published on: February 28, 2019

Innate immune evasion by staphylococci.

Karin Ellen Veldkamp1, Jos A G van Strijp

  • 1Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.

Advances in Experimental Medicine and Biology
|January 9, 2010
PubMed
Summary

Staphylococci bacteria deploy excreted proteins to overcome the human innate immune system. These proteins disrupt the immune cascade, enabling bacterial survival within the host.

Area of Science:

  • Microbiology
  • Immunology
  • Bacterial Pathogenesis

Background:

  • Bacteria face the human innate immune system upon host invasion.
  • Staphylococci are significant human pathogens requiring effective immune evasion strategies.

Purpose of the Study:

  • To describe the challenges Staphylococci face from the innate immune system.
  • To present recent findings on how Staphylococci counteract innate immunity.

Main Methods:

  • Analysis of bacterial evasion mechanisms.
  • Identification of excreted proteins involved in immune interference.

Main Results:

  • Staphylococci utilize a diverse array of small, excreted proteins.
  • These proteins interfere with critical steps of the innate immune cascade.

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Quantifying the Cytotoxicity of Staphylococcus aureus Against Human Polymorphonuclear Leukocytes

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Related Experiment Videos

Last Updated: Jun 17, 2026

A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection
09:15

A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection

Published on: February 28, 2019

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Quantifying the Cytotoxicity of Staphylococcus aureus Against Human Polymorphonuclear Leukocytes
12:27

Quantifying the Cytotoxicity of Staphylococcus aureus Against Human Polymorphonuclear Leukocytes

Published on: January 3, 2020

Conclusions:

  • Staphylococci possess sophisticated strategies to survive innate immune attacks.
  • Excreted proteins are key virulence factors for Staphylococci in the human host.