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[Allergic response to qingkailing injection in BN rats]
Shan-Shan Guo1, Yi-Zhong Wang, Yi Zhang
1Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|January 9, 2010
Summary
BN rats demonstrated a higher incidence and severity of allergic responses to Qingkailing injection compared to guinea pigs. These findings suggest BN rats are a suitable animal model for evaluating traditional Chinese medicine-induced allergies.
Area of Science:
- Pharmacology
- Immunology
- Toxicology
Background:
- Traditional Chinese medicine (TCM) safety evaluation requires robust animal models.
- Understanding allergic responses to TCM injections is crucial for patient safety.
Purpose of the Study:
- To observe allergic responses to Qingkailing injection in BN rats.
- To establish and validate BN rats as a suitable animal model for evaluating TCM-induced allergic reactions.
Main Methods:
- Sensitization of BN rats and guinea pigs with Qingkailing injection.
- Observation of allergic symptoms, serum/tissue histamine levels (ELISA), and HE staining for pathological changes in lung and trachea.
Main Results:
- BN rats exhibited a significantly higher incidence (52.78%) and degree of allergic response than guinea pigs (16.67%).
- Elevated histamine levels and more severe pathological changes in lung and trachea were observed in BN rats compared to controls and guinea pigs.
- Histamine release rate was higher in BN rats.
Conclusions:
- BN rats show a more pronounced allergic response to Qingkailing injection than guinea pigs.
- BN rats represent a promising and suitable animal model for assessing allergic responses to traditional Chinese medicine injections.
