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Updated: Jun 17, 2026
08:54
Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
Published on: February 14, 2018
[A novel azo-type compound from Dendrolobium triangulare].
Qian-Jun Zhang1, Xiao-Sheng Yang, Hai-Yan Zhu
1The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, China.
Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|January 9, 2010
Summary
Thirteen compounds were isolated from Dendrolobium triangulare, including a novel compound (1). This new compound demonstrated superior protection against PC12 cell damage compared to Vitamin E.
Area of Science:
- Phytochemistry
- Natural Products Chemistry
- Pharmacognosy
Context:
- Dendrolobium triangulare is a plant species with potential medicinal properties.
- Investigating the chemical constituents of medicinal plants is crucial for discovering new therapeutic agents.
Purpose:
- To isolate and characterize compounds from Dendrolobium triangulare.
- To evaluate the neuroprotective potential of isolated compounds.
Summary:
- Thirteen compounds were isolated and identified from Dendrolobium triangulare using chromatographic and spectroscopic methods.
- These compounds include beta-sitosterol, lupeol, betulinc acid, betulin, and a novel compound, azo-2, 2'-bis [Z-(2, 3-dihydroxy-4-methyl-5-methoxy) phenyl ethylene] (1).
- Compound 1 exhibited enhanced protection against glutamate-induced PC12 cell damage compared to Vitamin E.
Impact:
- This study expands the knowledge of Dendrolobium genus's chemical diversity.
- The novel compound 1 shows promise as a potential neuroprotective agent.
- Findings may guide future research into the therapeutic applications of Dendrolobium triangulare.
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