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Related Concept Videos

Nociception01:44

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...
Pain01:20

Pain

Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...

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Regenerative Peripheral Nerve Interface: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain
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Published on: March 15, 2024

Neuropathic pain.

Vanja Basić-Kes1, Iris Zavoreo, Marijana Bosnar-Puretić

  • 1University Department od Neurology, Reference Center for Neurovascular Disorders, Ministry of Health and Social Welfare of Republic of Croatia, Sestre milosrdnice University Hospital, Zagreb. vanjakes@net.hr

Acta Clinica Croatica
|January 9, 2010
PubMed
Summary

Neuropathic pain, caused by nervous system damage, presents challenges in treatment. Current therapies offer limited relief, with less than half of patients experiencing significant benefits from pharmacological drugs.

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Area of Science:

  • Neurology
  • Pain Medicine
  • Pharmacology

Background:

  • Neuropathic pain arises from nervous system pathology.
  • Common causes include diabetes, herpes zoster, nerve compression, and chemotherapy.
  • Key symptoms include mechanical allodynia and cold hyperalgesia.

Purpose of the Study:

  • To review the current landscape of neuropathic pain treatment.
  • To highlight the limitations of existing pharmacological interventions.
  • To underscore the need for improved therapeutic strategies.

Main Methods:

  • Review of randomized placebo-controlled trials.
  • Analysis of drug classes used for neuropathic pain management.
  • Assessment of treatment efficacy and patient outcomes.

Main Results:

  • Pharmacological treatments include adjuvant analgesics, opioids, and topical agents.
  • Combination drug therapies are frequently employed.
  • Less than 50% of patients achieve substantial benefit from current drugs.

Conclusions:

  • Despite research advancements, neuropathic pain treatment remains unsatisfactory.
  • Existing treatments show limited efficacy for a significant portion of patients.
  • Further research is crucial to develop more effective therapies for neuropathic pain.