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Published on: November 8, 2015
Treatment with twice-weekly tacrolimus ointment in patients with moderate to severe atopic dermatitis: results from
Sakari Reitamo1, Richard Allsopp
1Skin and Allergy Hospital, University of Helsinki, Helsinki, Finland. Sakari.Reitamo@hus.fi
Background:
Twice-weekly tacrolimus ointment for mild to severe atopic dermatitis (AD) significantly reduced the number of flares and prolonged flare-free intervals compared with standard treatment in the CONTROL studies.
Methods:
Post hoc analysis of data from the CONTROL studies was carried out on patients with moderate to severe disease. Patients applied tacrolimus 0.1% (adults; n = 183) or 0.03% (children; n = 166) ointment twice-daily for
Results:
Twice-weekly treatment significantly reduced the number of flares and time to first flare (p < 0.001). Around three times as many patients in each study had no flares of any severity throughout the double-blind period in the twice-weekly treatment group compared with the standard treatment group (p < 0.001). Improvements in symptoms and quality of life with twice-weekly treatment were above those observed with standard treatment. Twice-weekly treatment was well tolerated.
Conclusions:
A twice-weekly tacrolimus ointment regimen was effective in adults and children with moderate to severe AD.
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