Related Experiment Video
Updated: Jun 17, 2026

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
Published on: July 25, 2020
Targeting DAX-1 in embryonic stem cells and cancer
1Institut de Pharmacologie Moléculaire et Cellulaire CNRS UMR 6097, Valbonne, France. ninino@ipmc.cnrs.fr
Importance Of The Field:
DAX-1 (NR0B1) is an unusual orphan nuclear receptor whose function is essential for the development of the human adrenal cortex and onset of puberty. Recent data have implicated this transcription factor also in embryonic stem cell and cancer biology.
Areas Covered In This Review:
The role of DAX-1 in the regulation of development and function of the adrenal cortex, reproductive axis, embryonic stem cells and a few types of cancer.
What The Reader Will Gain:
Here we review the past and present milestones in DAX-1 research and try to provide hints about the development and fields of application of DAX-1-targeted drugs in the future.
Take Home Message:
The unusual structure and restricted expression pattern of DAX-1 may offer unique opportunities for drug discovery.

