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Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images (SDM-PSI)
Published on: November 27, 2019
Temporal and right frontal lobe alterations in panic disorder: a quantitative volumetric and voxel-based morphometric
T Sobanski1, G Wagner, G Peikert
1Department of Psychiatry and Psychotherapy, University of Jena, Germany. sobanskit@aol.com
Psychological Medicine
|January 9, 2010
Summary
Brain imaging reveals reduced temporal and frontal lobe volumes in panic disorder (PD) patients. These findings, particularly in the right middle temporal gyrus and orbitofrontal cortex, support neurobiological theories of PD.
Area of Science:
- Neuroimaging
- Neuroanatomy
- Psychiatry
Background:
- Panic disorder (PD) is a condition with ongoing neurobiological research.
- Previous theories suggest potential structural brain changes in PD.
Purpose of the Study:
- To investigate alterations in temporal and frontal lobe volumes in individuals with PD.
- To compare brain volumes between PD patients and healthy controls (HC).
Main Methods:
- Quantitative volumetric magnetic resonance imaging (MRI) was used.
- Seventeen in-patients with PD and matched HC subjects were analyzed.
- Voxel-based morphometry (VBM) assessed grey matter (GM) volume changes.
Main Results:
- Patients with PD showed reduced bilateral temporal lobe volume compared to HC.
- A decrease in right frontal lobe volume was observed in PD patients.
- VBM identified significant GM volume reduction in the right middle temporal gyrus (BA 21) and medial orbitofrontal cortex (BA 11) in PD.
Conclusions:
- Reduced temporal and frontal lobe volumes in PD align with existing research.
- VBM analysis provided precise localization of GM volume abnormalities.
- Findings support neurobiological models of panic disorder etiology.
