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[Relationship between the level of MCP-1 expression in sera of RA patients and ILD]
Tao Ling1, Hao-Zhe Lv, Yu-Xia Ma
1Department of Rheumatology and Immunology, The First Affiliated Hospital, China Medical University, Shenyang 110001, China. lintao_0825@126.com
Aim:
To investigate the function and clinical significance of monocyte chemoattractant protein-1 MCP-1 in the pathogenesis of rheumatoid arthritis(RA)and the relation ship between the expression of MCP-1 in serum and interstitial lung disease (ILD) secondary from RA.
Methods:
60 patients with RA were divided into two groups: 30 cases with simple RA group and 30 cases with ILD secondary from RA (RA+ILD group). The control group incuided 20 healthy cases. Enzyme linked immunosorbent assay (ELISA ) was used to determine the serum expression of MCP-1 in patients healthy controls. The differences of MCP-1 level and other laboratory indexes (IgG, IgA, IgM, alpha2-G, gamma-G, RF, ESR, CRP, and the number of arthrocele) in different groups were compared with software spss13.0.
Results:
The expression of MCP-1 in simple RA patients was significantly higher than that in the control group (P>0.05) and significantly lower than that in the RA+ILD group (P>0.01). The level of MCP-1 in serum of RA patieuts was positively correlated with IgG, IgM, and gamma-G.
Conclusion:
MCP-1 plays an important role in the pathogenesis of RA and may contribute to the promotion of lung fibrosis in ILD secondary from RA.
