Overweight and seminal quality: a study of 794 patients
Ana C Martini1, Andrea Tissera, Daniel Estofán
1Established investigator from the Consejo Nacional de Investigaciones Científicas y Tecnológicas, Instituto de Fisiología, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina. acmartini2000@yahoo.com
Objectives:
To evaluate sperm quality, levels of markers of epididymal and accessory gland function, and T in semen from men grouped according to their body mass index (BMI).
Design:
Blind prospective study.
Setting:
Andrology and reproduction laboratory in Cordoba, Argentina (2006-2007).
Patient(S):
Seven hundred ninety-four men.
Intervention(S):
None.
Main Outcome Measure(S):
In semen samples, sperm quality (volume, density, motility, morphology, viability, hypoosmotic swell test, and nuclear maturity) and levels of neutral alpha-glucosidase, fructose, citric acid and T.
Result(S):
Multivariate analysis showed a negative association between BMI and motility, rapid motility and neutral alpha-glucosidase levels, and a positive association between BMI and seminal fructose levels. No associations were found among BMI and sperm concentration, the other parameters evaluated, or seminal T levels.
Conclusion(S):
Results found in our study support a deleterious effect of obesity on seminal quality, probably by alterations in the function of the epididymis (i.e., in epididymal maturation).
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