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Changes of CD4+CD25high regulatory T cells and FOXP3 expression in unexplained recurrent spontaneous abortion
Shanshan Mei1, Jianping Tan, Hui Chen
1Department of Obstetrics and Gynecology, Second Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China.
Objective:
To investigate the proportions of CD4+CD25high T cells and forkhead box p3 (FOXP3) expression in peripheral blood and decidua in patients with unexplained recurrent spontaneous abortion (URSA).
Design:
Prospective clinical study.
Setting:
University hospital.
Patient(S):
125 URSA patients, 35 normal early pregnant women, and 28 normal nonpregnant women.
Intervention(S):
Measurements of CD4+CD25high T cells and FOXP3 expression in peripheral blood and decidua.
Main Outcome Measure(S):
The proportions of CD4+CD25high T cells and FOXP3 expression.
Result(S):
In peripheral blood, statistically significantly higher proportions of CD4+CD25high T cells and FOXP3 expression were observed in normal early pregnant women compared with normal nonpregnant women and URSA patients; a statistically significantly lower proportion of CD4+CD25high T cells was observed in nonpregnant URSA patients compared with URSA patients who had early miscarriages and normal nonpregnant women. In the decidua, statistically significantly lower proportions of CD4+CD25high T cells and FOXP3 expression were found in URSA patients with early miscarriages compared with normal early pregnant women.
Conclusion(S):
The CD4+CD25high T cells may play an important role in maintaining a normal pregnancy. The reduction in CD4+CD25high T cells may involve in the pathogenesis of URSA, and is correlated with lower FOXP3 expression.
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