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Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
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Prenatal exposure to PBDEs and neurodevelopment.

Julie B Herbstman1, Andreas Sjödin, Matthew Kurzon

  • 1Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, Columbia Center for Children's Environmental Health, New York, New York 10032 , USA. jh2678@columbia.edu

Environmental Health Perspectives
|January 9, 2010
PubMed
Summary

Prenatal exposure to polybrominated diphenyl ethers (PBDEs), common flame retardants, is linked to lower neurodevelopmental scores in children. This study highlights potential risks of these persistent environmental contaminants.

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Area of Science:

  • Environmental Health
  • Neuroscience
  • Toxicology

Background:

  • Polybrominated diphenyl ethers (PBDEs) are persistent, bioaccumulative flame retardants found globally.
  • Animal studies indicate prenatal PBDE exposure may negatively impact neurodevelopment.
  • This research investigates PBDEs as ubiquitous environmental contaminants with potential health implications.

Purpose of the Study:

  • To examine the association between prenatal exposure to PBDEs and child neurodevelopment.
  • To assess neurodevelopmental outcomes at multiple time points (12-72 months) in a longitudinal cohort.
  • To analyze specific PBDE congeners in relation to cognitive and motor development.

Main Methods:

  • A longitudinal cohort study of 329 mothers in lower Manhattan, New York, post-9/11/2001.
  • Analysis of 210 cord blood specimens for PBDE congener concentrations.
  • Multivariate regression models used to assess neurodevelopmental indices at 12, 24, 36, 48, and 72 months.

Main Results:

  • Elevated cord blood concentrations of BDE-47, BDE-99, and BDE-100 were detected.
  • Higher PBDE levels correlated with lower scores on mental and physical development tests.
  • Significant associations observed between specific PBDE congeners and developmental indices at various ages.

Conclusions:

  • This epidemiologic study provides evidence of neurodevelopmental effects linked to prenatal PBDE exposure.
  • Findings suggest a potential risk of PBDEs to child neurodevelopment.
  • Further longitudinal studies are recommended for confirmation.