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Arterial pulse wave velocity and peritoneal transport characteristics independently predict hospitalization in

Ni Gao1, Bonnie Ching-Ha Kwan, Kai-Ming Chow

  • 1Department of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis
|January 9, 2010
PubMed

Insights

Arterial stiffness and high peritoneal transport in peritoneal dialysis patients predict cardiovascular disease hospitalizations. Radiographic fluid overload measures did not correlate with these factors.

Area of Science:

  • Nephrology
  • Cardiology
  • Vascular Medicine

Background:

  • Cardiovascular disease (CVD) is a leading cause of mortality in chronic peritoneal dialysis (PD) patients.
  • Increased arterial stiffness and systemic fluid overload are potential contributors to CVD risk in PD.
  • Peritoneal membrane permeability may influence fluid status and vascular health.

Purpose of the Study:

  • To investigate the relationship between arterial stiffness, peritoneal transport, and radiographic indicators of fluid overload in Chinese PD patients.
  • To identify predictors of cardiovascular disease hospitalizations and mortality in this cohort.

Main Methods:

  • Prospective cohort study of 107 PD patients at a university referral center.
  • Arterial stiffness assessed by carotid-femoral (C-F) and carotid-radial pulse wave velocity (PWV).
  • Peritoneal transport evaluated by dialysate-to-plasma creatinine ratio (D/P) and radiographic measures of fluid overload.

Main Results:

  • No correlation found between radiographic measures, arterial PWV, and D/P creatinine.
  • Carotid-femoral PWV and D/P creatinine independently predicted the number of hospitalizations for CVD.
  • No studied parameters correlated with overall mortality.

Conclusions:

  • Arterial stiffness and high peritoneal transport are independent predictors of CVD hospitalizations in PD patients.
  • Radiographic parameters of fluid overload did not correlate with arterial stiffness or peritoneal transport.
  • Findings suggest that arterial stiffness and high peritoneal transport individually contribute to CVD development in PD patients.
Abstract

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