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Green Fluorescent Protein-based Expression Screening of Membrane Proteins in Escherichia coli
Published on: January 6, 2015
Straight talk with... Eric Green. Interview by Erica Westly
Nature Medicine
|January 9, 2010
Summary
Genomics research faces challenges in complex diseases, despite early Human Genome Project successes. The National Human Genome Research Institute (NHGRI) head discusses the future of genomics in medicine.
Area of Science:
- Genomics and Bioinformatics
- Medical Genetics
- Health Services Research
Background:
- Eric Green, new NHGRI director, has a long history in genomics, contributing to the Human Genome Project.
- Early human genome sequencing showed vast potential for medical applications.
- Most complex disorders have proven difficult to address with current genomic understanding.
Discussion:
- Critics question the emphasis on genetic underpinnings of diseases.
- The rise of comparative effectiveness research raises concerns about overlooking genomic factors.
- Francis Collins (former NHGRI head) worries genomic differences may be overlooked.
Key Insights:
- Genomics' potential in medicine is tempered by the complexity of most diseases.
- The field grapples with balancing genetic discovery with clinical application.
- Integrating genomic insights into healthcare remains a significant challenge.
Outlook:
- The NHGRI aims to define its role in the evolving American healthcare system.
- Future directions involve navigating the complexities of genomic medicine.
- Addressing the limitations of current genomic knowledge for diverse medical conditions is crucial.
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