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T1rho and T2rho MRI in the evaluation of Parkinson's disease

I Nestrasil1, S Michaeli, T Liimatainen

  • 1Department of Neurology, University of Minnesota, MMC 295; 420 Delaware Street SE, Minneapolis, MN 55455, USA. nestr007@umn.edu

Journal of Neurology
|January 9, 2010
PubMed

Insights

This study shows that magnetic resonance imaging (MRI) measures, T(1rho) and T(2rho), can differentiate Parkinson's disease (PD) patients from healthy individuals. T(1rho) may also indicate disease asymmetry in PD.

Area of Science:

  • Neuroimaging
  • Biophysics

Background:

  • Adiabatic T(1rho) and T(2rho) relaxation time constants show potential for detecting cellular changes and iron presence in Parkinson's disease (PD).
  • Understanding the relationship between these MRI parameters and PD severity/progression is crucial.

Purpose of the Study:

  • To investigate the utility of T(1rho) and T(2rho) magnetic resonance imaging (MRI) in differentiating Parkinson's disease (PD) patients from controls.
  • To explore the correlation between T(1rho) and T(2rho) values in the substantia nigra (SN) and PD motor features.

Main Methods:

  • Utilized a 4T MRI scanner to measure T(1rho) and T(2rho) relaxation times.
  • Assessed the substantia nigra (SN) in nine non-demented, moderately affected PD patients and ten age/gender-matched controls.

Main Results:

  • PD subjects exhibited increased T(1rho) and reduced T(2rho) in the SN compared to controls.
  • A significant correlation was found between asymmetric motor features and T(1rho) asymmetry.

Conclusions:

  • T(1rho) and T(2rho) MRI methods are validated as effective in distinguishing PD patients from control subjects.
  • T(1rho) shows promise as a potential biomarker for assessing motor asymmetry in Parkinson's disease.

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