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Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...

Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.

Stem Cell Culture

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

Maintenance of the ES Cell State

Maintenance of the ES Cell State

The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

EPS and iPS Cells in Disease Research

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

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Related Experiment Video

Updated: Jun 17, 2026

Propagation of Human Embryonic Stem (ES) Cells

Propagation of Human Embryonic Stem (ES) Cells

Published on: November 30, 2006

Developments and challenges in human embryonic stem cell research in Spain.

R P Cervera¹, M Stojkovic

¹Cellular reprogramming laboratory, Prince Felipe Research Centre (CIPF), 46012 Valencia, Spain.

Stem Cell Reviews and Reports

|January 9, 2010

Summary

Spain is investing in regenerative medicine, building a collaborative network across public and private sectors. Overcoming challenges is key to establishing Spain as a global leader in this scientific field.

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Area of Science:

Regenerative Medicine
Biomedical Research
Healthcare Innovation

Background:

Spain is actively developing its scientific capabilities, particularly in the field of regenerative medicine.
A collaborative network is being established, integrating public and private institutions across various research stages.
Significant economic and infrastructure investments have been made, with results anticipated over time.

Purpose of the Study:

To provide an overview of Spain's progress in regenerative medicine.
To identify challenges that have been overcome and those that remain.
To outline the strategy for positioning Spain as a world reference in regenerative medicine.

Main Methods:

Analysis of Spain's scientific and infrastructural investments in regenerative medicine.
Review of the collaborative network structure involving diverse research institutions.
Assessment of progress and remaining hurdles in the field.

Main Results:

Spain is establishing a robust collaborative network for regenerative medicine research.
Significant investments in infrastructure and funding are in place.
Key challenges have been addressed, with ongoing efforts to overcome remaining obstacles.

Conclusions:

Spain is making a concerted effort to become a leader in regenerative medicine.
Collaboration between public and private entities is crucial for success.
Continued strategic development is necessary to achieve global reference status.