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Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
Published on: June 17, 2025
Laryngeal mucous membrane pemphigoid: a systematic review and pooled-data analysis
Thomas S Higgins1, Justin C Cohen, John T Sinacori
1Department of Otolaryngology-Head and Neck Surgery, Norfolk, Virginia, USA.
The Laryngoscope
|January 9, 2010
Summary
Laryngeal mucous membrane pemphigoid (MMP) is a rare condition affecting approximately one in 10 million people. Early diagnosis and consistent follow-up are crucial for managing this potentially life-threatening disease.
Area of Science:
- Otolaryngology
- Immunodermatology
- Rare Diseases
Background:
- Laryngeal mucous membrane pemphigoid (MMP) is a rare autoimmune blistering disease affecting the larynx.
- Limited literature exists on the epidemiology and clinical characteristics of laryngeal MMP.
Purpose of the Study:
- To conduct a systematic pooled-data analysis of existing literature on laryngeal MMP.
- To determine the prevalence, clinical features, and outcomes of laryngeal MMP.
Main Methods:
- Systematic literature search across multiple databases (MEDLINE, EMBASE, etc.).
- Inclusion of case reports and case series; exclusion of clinical trials.
- Pooled-data and Kaplan-Meier survival analyses were performed.
Main Results:
- Analysis of 141 patients from 63 case reports and 10 case series.
- Prevalence estimated at 12.2% of MMP cases or 1 in 10 million persons.
- Supraglottis most affected site; antiepiligrin autoantibodies associated with increased laryngeal involvement.
- 5-year survival rate of 92.4%; 10.5% required tracheostomy, with surgery effective in severe cases.
Conclusions:
- Laryngeal MMP is a rare but potentially life-threatening condition.
- Effective management requires prompt diagnosis and diligent follow-up.
- While medical therapy can help, relapses are common, and surgical intervention may be necessary for severe cases.
