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Updated: Jun 17, 2026

Personalized Needles for Microinjections in the Rodent Brain
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Personalized Needles for Microinjections in the Rodent Brain

Published on: January 24, 2018

Needles: a comparison study.

Gerhard Mayer1, Volker Knappertz, Peter Kinast

  • 1Bayer HealthCare Pharmaceuticals Inc., Montville, New Jersey 07045, USA. gerhard.mayer@bayer.com

Medical Device Technology
|January 12, 2010
PubMed
Summary
This summary is machine-generated.

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Needle comfort is crucial for patients with multiple sclerosis (MS) using injectable therapies. This study compared MS therapy needles, recommending manufacturers develop less traumatic, lower-force needles to improve patient comfort.

Area of Science:

  • Medical device engineering
  • Patient-centered care
  • Immunology

Background:

  • Self-administration of injectable therapies is common for chronic conditions like multiple sclerosis (MS).
  • Patient comfort during injections is a significant factor influencing treatment adherence and quality of life.
  • Minimizing physical trauma associated with needle use is essential for improving the patient experience.

Purpose of the Study:

  • To compare the penetration forces of different needles used for administering multiple sclerosis therapies.
  • To identify potential improvements in needle design that could enhance patient comfort.
  • To advocate for the development of less traumatic injection devices for MS patients.

Main Methods:

  • A comparative study was conducted to evaluate various needles utilized in MS therapy administration.

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Last Updated: Jun 17, 2026

Personalized Needles for Microinjections in the Rodent Brain
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Published on: January 24, 2018

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  • Penetration force measurements were likely employed to quantify the physical resistance of different needle types.
  • Data analysis focused on identifying needles with lower penetration forces.

    • Main Results:

    • The study identified variations in penetration forces among the tested needles.
    • Certain needle designs may offer improved comfort due to reduced penetration force.
    • A need for further development in needle technology for MS therapies was highlighted.

    Conclusions:

    • Needle selection and design significantly impact patient comfort during self-administered MS therapies.
    • Medical device manufacturers should prioritize the development of needles with decreased penetration forces.
    • Reducing needle-induced trauma can lead to enhanced patient comfort and potentially improve treatment adherence in multiple sclerosis management.