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Related Experiment Video

Updated: Jun 17, 2026

Inducing Pseudopregnancy in Female Mice Without the Need for Vasectomized Males Prior to Non-Surgical Embryo Transfer or Artificial Insemination
05:36

Inducing Pseudopregnancy in Female Mice Without the Need for Vasectomized Males Prior to Non-Surgical Embryo Transfer or Artificial Insemination

Published on: July 7, 2023

Mild stimulation in assisted reproduction.

Pedro N Barri1, Rosa Tur, Francisca Martinez

  • 1Department of Gynecology, Obstetrics and Reproductive Medicine, Institut Universitari Dexeus, Gran Vía de Carlos III, Barcelona, Spain. pbarri@dexeus.com

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
|January 12, 2010
PubMed
Summary

Mild ovarian stimulation protocols, combined with embryo cryopreservation, offer comparable pregnancy rates to conventional methods. This approach reduces costs and multiple pregnancies in fertility treatments.

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Last Updated: Jun 17, 2026

Inducing Pseudopregnancy in Female Mice Without the Need for Vasectomized Males Prior to Non-Surgical Embryo Transfer or Artificial Insemination
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Published on: July 7, 2023

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Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Published on: September 16, 2021

Human Egg Maturity Assessment and Its Clinical Application
08:51

Human Egg Maturity Assessment and Its Clinical Application

Published on: August 19, 2019

Area of Science:

  • Reproductive Medicine
  • In Vitro Fertilization (IVF)

Background:

  • Conventional ovarian stimulation protocols present drawbacks including intense stimulation and high financial costs.
  • Mild stimulation and friendly in vitro fertilization (IVF) are gaining patient popularity but face medical reluctance.

Purpose of the Study:

  • To evaluate the efficacy of mild ovarian stimulation protocols in achieving pregnancy rates comparable to conventional methods.
  • To assess the role of embryo cryopreservation in conjunction with mild stimulation protocols.
  • To investigate the impact of these combined approaches on reducing multiple pregnancies and treatment costs.

Main Methods:

  • Observational study comparing mild stimulation protocols with conventional methods.
  • Analysis of pregnancy rates based on oocyte yield (specifically, if more than five oocytes were obtained).
  • Evaluation of cumulative pregnancy rates incorporating embryo cryopreservation programs.

Main Results:

  • Mild stimulation yields fewer oocytes but does not compromise pregnancy rates when at least five oocytes are retrieved.
  • Embryo cryopreservation programs combined with mild stimulation achieve cumulative pregnancy rates similar to conventional protocols.
  • The combination of mild stimulation and selective embryo transfer significantly reduces multiple pregnancies and overall treatment costs.

Conclusions:

  • Mild ovarian stimulation protocols are a viable alternative to conventional methods, particularly when combined with embryo cryopreservation.
  • These protocols offer a cost-effective and safer approach to fertility treatment by minimizing multiple pregnancies.
  • Further adoption of mild stimulation and embryo cryopreservation is recommended for infertile patients.