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Updated: Jun 17, 2026

Intracavernosal Pressure Recording to Evaluate Erectile Function in Rodents

Intracavernosal Pressure Recording to Evaluate Erectile Function in Rodents

Published on: June 6, 2018

A new perfusion model for studying erectile function.

Chen Zhao¹, Han Jung Chae, Suhn Hee Kim

¹Department of Urology, Medical School, and Institute for Medical Sciences, Chonbuk National University, and Research Institute of Clinical Medicine and CTC for Medical Device of Chonbuk National University Hospital, Jeonju 561-712, Korea.

The Journal of Sexual Medicine

|January 12, 2010

Summary

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A new in vitro penile perfusion model effectively measures intracavernosum pressure (ICP) and cyclic guanosine monophosphate (cGMP) changes. This model offers advantages over traditional methods for studying penile physiology and erectile function.

Area of Science:

Physiology
Pharmacology
Urology

Background:

A novel in vitro penile perfusion model was developed for simultaneous measurement of intracavernosum pressure (ICP), tension, and cyclic nucleotides.
This model allows for a one-step procedure to assess penile tissue responses.

Purpose of the Study:

To compare the newly developed penile perfusion model with the classical penile strip chamber model.
To investigate the role of the nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathway in penile function using both models.

Main Methods:

Investigated the NO-cGMP pathway activated by acetylcholine or electrical field stimulation (EFS).
Measured cyclic guanosine monophosphate (cGMP) in penile corpus cavernosum smooth muscle and perfusates.
Determined ICP, tension, and cGMP simultaneously in the penile perfusion model.

Related Experiment Videos

Last Updated: Jun 17, 2026

Intracavernosal Pressure Recording to Evaluate Erectile Function in Rodents

Intracavernosal Pressure Recording to Evaluate Erectile Function in Rodents

Published on: June 6, 2018

Main Results:

Acetylcholine and EFS induced concentration- and frequency-dependent relaxation and decreased tension in both models.
Pharmacological blockade (atropine, L-NAME, ODQ) inhibited acetylcholine-induced responses.
Both stimuli increased cGMP levels, with responses attenuated by inhibitors (TTX, atropine, L-NAME, ODQ).

Conclusions:

The penile perfusion model demonstrated similar responses to the penile strip model regarding tension and cGMP levels.
The new model offers superior advantages for measuring intracavernosum metabolic changes and ICP without procedural interruption.