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Visualizing Hyporheic Flow Through Bedforms Using Dye Experiments and Simulation
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Riser's reflux--an eye-opening experience.

C-H Poh1, L Allen, I Malagon

  • 1Department of Medicine, Southern Arizona VA Health Care System, University Arizona Health Sciences Center, Tucson, AZ 85723-0001, USA.

Neurogastroenterology and Motility
|January 12, 2010
PubMed
Summary
This summary is machine-generated.

Morning acid reflux, known as riser's reflux, is common in gastro-oesophageal reflux disease (GORD) patients, potentially explaining early morning symptoms. This study compared reflux events before and after waking in GORD patients and healthy individuals.

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Area of Science:

  • Gastroenterology
  • Sleep Medicine
  • Diagnostic Technology

Background:

  • Gastro-oesophageal reflux disease (GORD) patients frequently experience morning symptoms like sour or bitter taste.
  • The occurrence of acid reflux events around the time of awakening is not well understood.

Purpose of the Study:

  • To compare the prevalence and frequency of acid reflux events before and immediately after waking in GORD patients versus healthy controls.
  • To investigate the phenomenon of 'riser's reflux' in GORD.

Main Methods:

  • Thirty-nine GORD patients and nine healthy controls underwent pH testing combined with actigraphy.
  • A novel technology integrated raw actigraphy and pH monitoring data.
  • Acid reflux events were analyzed up to 1 hour before and 10-20 minutes after awakening.

Main Results:

  • Nearly half (48.7%) of GORD patients experienced acid reflux within 20 minutes after waking, compared to 17.9% in the hour prior.
  • GORD patients had significantly more acid reflux events after waking (60 events in 20 min) than before (14 events in 1 hr, P < 0.05).
  • No reflux events were observed in healthy controls during the studied periods (P < 0.001).

Conclusions:

  • Riser's reflux is a common occurrence in GORD patients.
  • This post-awakening reflux may be responsible for the characteristic early morning symptoms reported by GORD sufferers.