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Setup and Execution Of the Blindfolded Code Training Exercise
Published on: March 29, 2019
Outsmarting a mastermind
1Regulatory Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037-1099, USA. jones@salk.edu
Developmental Cell
|January 12, 2010
Abstract:
Moellering et al. recently reported that a cell-permeable "stapled" synthetic peptide of the Notch coactivator Mastermind is a potent dominant-negative inhibitor of oncogenic Notch signaling in T cell acute lymphoblastic leukemia. This new class of inhibitor may find broad utility in blocking protein-protein interactions that underlie many human diseases.
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For the first part of the problem,...