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Lymphadenitis caused by H1N1 vaccination: case report
Hatice Toy1, Deniz Karasoy1, Melike Keser2
1Selcuk University, Meram Medicine Faculty, Department of Pathology, Akyokus-Konya, Turkey.
Vaccine
|January 12, 2010
Summary
A painful lymph node developed after H1N1 vaccination. Pathological examination revealed reactive lymphadenitis, suggesting a potential vaccine side effect rather than lymphoma.
Area of Science:
- Immunopathology
- Vaccinology
- Surgical Pathology
Background:
- A supraclavicular painful mass prompted hospital admission.
- Initial ultrasonography revealed solitary lymphadenopathy.
Observation:
- The mass measured 1x0.8x0.8 cm, appearing round, yellow-brown, and slightly soft.
- Pathologic examination showed capsular edema and preserved lymph node architecture.
- Marked proliferation of CD30-positive immunoblasts, including atypical forms resembling mononuclear Hodgkin cells, was noted.
Findings:
- The histological findings indicated reactive lymphadenitis.
- The immunophenotype of atypical immunoblasts was positive for CD30.
- Differential diagnosis initially considered Hodgkin lymphoma due to CD30 expression.
Implications:
- The findings suggest that H1N1 vaccination may be associated with reactive lymphadenitis.
- This case highlights the importance of considering vaccine side effects in the differential diagnosis of lymphadenopathy.
- Further investigation may be warranted to understand the immunologic response to H1N1 vaccination manifesting as lymphadenopathy.
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