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Updated: Jun 17, 2026

Genetic Manipulation of Cerebellar Granule Neurons In Vitro and In Vivo to Study Neuronal Morphology and Migration
Published on: March 17, 2014
The dynamic ubiquitin ligase duo: Cdh1-APC and Cdc20-APC regulate neuronal morphogenesis and connectivity
Yue Yang1, Albert H Kim, Azad Bonni
1Department of Pathology, Harvard Medical School, Boston, MA 02115, USA; Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA.
None:
The proper development and patterning of axons, dendrites, and synapses is essential for the establishment of accurate neuronal circuits in the brain. A major goal in neurobiology is to identify the mechanisms and principles that govern these fundamental developmental events of neuronal circuit formation. In recent years, exciting new studies have suggested that ubiquitin signaling pathways may play crucial roles in the control of neuronal connectivity. Among E3 ubiquitin ligases, Cdh1-anaphase promoting complex (Cdh1-APC) and Cdc20-APC have emerged as key regulators of diverse aspects of neuronal connectivity, from axon and dendrite morphogenesis to synapse differentiation and remodeling.
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