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Related Concept Videos

Thermosensation01:43

Thermosensation

35.6K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
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G-Protein Gated Ion Channels01:21

G-Protein Gated Ion Channels

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GPCRs are primarily responsible for our sense of smell, taste, and vision.  The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory...
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Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

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Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
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Antihypertensive Drugs: Action of Calcium Channel Blockers01:18

Antihypertensive Drugs: Action of Calcium Channel Blockers

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Calcium ions are essential to contract smooth muscle cells in blood vessels. They enter these cells through voltage-dependent calcium channels, specifically L-type calcium channels in the cell membrane. These L-type calcium channels are integral to the excitation-contraction coupling process in smooth muscle. When a stimulus is received by smooth muscle cells, their membrane depolarizes. This alteration in membrane potential instigates the opening of L-type calcium channels. As a result,...
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Arteries and Arterioles01:16

Arteries and Arterioles

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Arteries, the vasculature responsible for transporting blood from the heart, possess robust walls capable of enduring the elevated pressures exerted by the heartbeat. Arteries near the heart are especially thick-walled and enriched with elastic fibers across their three tunics, classifying them as elastic or conducting arteries. These arteries, usually with a diameter exceeding 10 mm, are characterized by their ability to dilate in response to the blood pumped from the heart's ventricles...
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Autoregulation of Blood Flow01:17

Autoregulation of Blood Flow

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Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation....
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Related Experiment Video

Updated: Apr 20, 2026

Exploring Arterial Smooth Muscle Kv7 Potassium Channel Function using Patch Clamp Electrophysiology and Pressure Myography
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TRP channels and the control of vascular function.

Anke Di1, Asrar B Malik

  • 1Department of Pharmacology, College of Medicine, University of Illinois, Chicago, IL 60612, USA.

Current Opinion in Pharmacology
|January 12, 2010
PubMed
Summary

Transient Receptor Potential (TRP) channels, crucial cation channels permeable to Ca2+, play vital roles in vascular functions. This review highlights their diverse roles in controlling blood vessel activity.

Area of Science:

  • Physiology
  • Molecular Biology
  • Cardiovascular Research

Background:

  • Mammalian Transient Receptor Potential (TRP) channels are a superfamily of cation channels.
  • They are classified into six subfamilies (TRPC, TRPM, TRPV, TRPA, TRPP, and TRPML) based on sequence homology.
  • Most TRP channels are nonselective cation channels, with significant permeability to Ca2+.

Purpose of the Study:

  • To review the current understanding of TRP channel functions in mammalian vascular systems.
  • To highlight the diverse roles of TRP channels in regulating vascular tone, permeability, and cellular processes.
  • To explore the various stimuli that activate TRP channels and their implications for vascular health.

Main Methods:

  • Literature review of existing research on TRP channels and vascular function.

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  • Analysis of studies investigating TRP channel activation mechanisms.
  • Synthesis of evidence linking TRP channels to endothelial permeability, oxidative stress, myogenic tone, proliferation, and thermoregulation.

    • Main Results:

    • TRP channels are implicated in critical vascular functions, including endothelial permeability and myogenic tone.
    • They respond to a wide array of stimuli such as mechanical stress, temperature changes, and receptor activation.
    • Evidence suggests TRP channels are involved in cellular proliferation and thermoregulation within the vasculature.

    Conclusions:

    • TRP channels are essential regulators of vascular homeostasis and function.
    • The diverse activation mechanisms of TRP channels underscore their multifaceted roles in the cardiovascular system.
    • Further research into TRP channels offers potential therapeutic targets for vascular diseases.