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Updated: Jun 17, 2026

Cholesterol Efflux Assay
Published on: March 6, 2012
Regulation of cholesterol homeostasis by liver X receptors
Yan-Wei Hu1, Lei Zheng, Qian Wang
1Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
Abstract:
Cellular cholesterol levels reflect a balance between uptake, efflux, and endogenous synthesis. The sterol-responsive transcription factors liver X receptors (LXRalpha and LXRbeta) help maintain cholesterol homeostasis, not only through promotion of cholesterol efflux from peripheral tissues but also through suppression of de novo synthesis and exogenous cholesterol uptake. In this review, we summarize the important role of LXRs in regulating expression of key members that keep cholesterol levels in balance.
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