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Updated: Jun 17, 2026

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
07:02

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development

Published on: February 11, 2019

The cholinergic system, sigma-1 receptors and cognition

Aren van Waarde1, Nisha K Ramakrishnan, Anna A Rybczynska

  • 1Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands. a.van.waarde@ngmb.umcg.nl

Behavioural Brain Research
|January 12, 2010
PubMed
Summary

Sigma-1 receptor agonists show promise for treating memory deficits and cognitive disorders by modulating the cholinergic system. These compounds demonstrate significant anti-amnesic and neuroprotective effects in various animal models.

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