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Updated: Jun 17, 2026

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance
Published on: February 17, 2023
Infliximab and insulin resistance.
Francesco Ursini1, Saverio Naty, Rosa Daniela Grembiale
1Rheumatology Research Unit, Department of Experimental and Clinical Medicine, University of Catanzaro UMG, Catanzaro, Italy. francesco.ursini@yahoo.it
Tumor necrosis factor-alpha (TNF-alpha) blockade may improve insulin resistance in non-diabetic patients with rheumatic diseases. This review examines scientific evidence on TNF-alpha
Area of Science:
- Rheumatology
- Endocrinology
- Immunology
Background:
- Insulin resistance is central to obesity, type 2 diabetes, and prediabetes.
- Tumor necrosis factor-alpha (TNF-alpha), a proinflammatory cytokine, contributes to inflammation-associated insulin resistance in rheumatic diseases.
Purpose of the Study:
- To review scientific literature on the potential of TNF-alpha blockade to improve insulin resistance in non-diabetic rheumatic patients.
Main Methods:
- Literature review of studies investigating TNF-alpha blockade and insulin resistance in rheumatic diseases.
Main Results:
- TNF-alpha plays a key role in inflammation-associated insulin resistance.
- Infliximab, a TNF-alpha inhibitor, shows promise in managing rheumatic diseases and inflammation.
Conclusions:
- TNF-alpha blockade is a potential therapeutic strategy for improving insulin resistance in non-diabetic individuals with rheumatic conditions.
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